A shocking discovery that traditional medicine missed and the breakthrough treatments now available.

*This article is written with patient's consent and encouragement; name has been changed for patient's privacy.

The Phone Call That Changed Everything

Sarah Martinez thought she was healthy. At 47, she exercised regularly, ate well, and had no cardiovascular disease events except for a family history of heart disease. Her annual checkups always came back with cholesterol at higher ranges but not extremely high, blood pressure normal, everything her doctor expected to see.

Then came the call about her HealthieOne Complete results.

"Your lipoprotein(a) is 317 nmol/L," the doctor explained. "That puts you in the highest risk category for heart attack and stroke."

Sarah had never even heard of lipoprotein(a). Neither had most of her friends. But this single biomarker discovery would soon reveal why 1 in 5 people carry a genetic time bomb that standard medical testing completely ignores.

The Silent Epidemic Hiding in Plain Sight

Here's what your doctor probably hasn't told you about lipoprotein(a):

Lipoprotein(a), or Lp(a), is a deadly variant of "bad" cholesterol that's entirely genetic 1. You're either born with elevated levels, or you're not. No amount of kale, cardio, or meditation will change it.

The terrifying statistics:

  • 20% of the population has dangerously high Lp(a) levels 2
  • It triples your risk of heart attack and stroke 3
  • 95% of people with high Lp(a) don't know they have it
  • Standard cholesterol panels don't test for it 1
  • Most heart attacks in "healthy" people involve elevated Lp(a) 4

Think about that: One in five people walking around with a genetic predisposition to sudden cardiac death, completely unaware, because their routine blood work looks "normal."

Why Your "Perfect" Cholesterol Test is Dangerously Incomplete

Here's the problem with standard medical testing: it's designed to catch problems that have already started causing damage, not prevent them from happening in the first place.

Traditional lipid panels test for:

  • Total cholesterol
  • LDL ("bad") cholesterol
  • HDL ("good") cholesterol
  • Triglycerides

What they miss:

  • Lipoprotein(a): the genetic cardiovascular risk factor
  • Advanced lipid particles that predict heart disease
  • Inflammatory markers that signal arterial damage
  • Metabolic dysfunction that precedes diabetes by years

It's like checking if your car's gas tank is full while ignoring the fact that the brakes are failing.

The Lifestyle Lie: When Healthy Living Isn't Enough

Sarah discovered something that shattered her worldview: genetics don't care about your lifestyle choices.

Unlike regular cholesterol, Lp(a) levels are:

  • Determined at birth by your genes 1
  • Unchanged by diet: even the strictest Mediterranean diet won't budge it 1
  • Unresponsive to exercise - marathon runners can have sky-high levels
  • Actually, increased by statins - the very drugs meant to protect your heart 5

"I felt betrayed," Sarah recalls. "I'd done everything right, and it didn't matter. My body was programmed to have a heart attack, and no one had ever tested for it."

HealthieOne coordinated with Sarah's primary care physician (PCP), Dr. Thomas Lynch, and she was able to schedule an appointment with him the same week. Dr. Lynch ordered lipoprotein(a) testing again; the number came back at 315 nmol/L. He was able to refer Sarah to his colleague cardiologist shortly after that.

This is the cruel reality for millions of Americans who believe they're healthy based on incomplete information.

The Medical Breakthrough That Changes Everything

Here's where Sarah's story takes a dramatic turn for the better.

Just five years ago, elevated Lp(a) was essentially a death sentence with no treatment options. Today, revolutionary therapies are making the impossible possible:

1. PCSK9 Inhibitors (Available Now)

Repatha (evolocumab) can reduce Lp(a) by 20-25% while dramatically lowering overall cardiovascular risk 6. Sarah's cardiologist started her on this immediately.

2. The RNA Revolution (Coming Soon)

  • Lepodisiran (Eli Lilly): A single injection that reduced Lp(a) by 94% for six months in clinical trials 2. Imagine a twice-yearly shot that virtually eliminates your genetic heart attack risk.
  • Pelacarsen (Novartis): Monthly injections showing 80% reductions in Lp(a) levels, currently in Phase 3 trials 89.
  • Olpasiran (Amgen): Another breakthrough siRNA treatment targeting the root genetic cause of elevated Lp(a) 7.

"These aren't incremental improvements," explains Dr. Michael Chen, interventional cardiologist at Stanford. "We're talking about treatments that can essentially turn off the genetic switch for elevated Lp(a). It's like having a cure for a genetic disease."

The $475 Test That Could Save Your Life

Sarah's discovery came through HealthieOne Complete, an at-home blood test that analyzes over 230+ biomarkers, including Lp(a) and dozens of other cardiovascular risk factors that standard panels miss.

Here's what makes HealthieOne different:

Comprehensive Beyond Compare

  • 230+ biomarkers vs. 12-15 in standard panels
  • Advanced metabolomics trusted by medical institutions like Johns Hopkins and Mayo Clinic
  • Genetic risk factors like Lp(a) that most doctors never test
  • Early disease detection years before symptoms appear

Convenience That Actually Works

  • Painless at-home collection using the Tasso+ device
  • 3-5 day results with physician interpretation included
  • Bundles a one-on-one doctor consult after result delivery and additional support as needed at your convenience through their live communication platform at https://healthieone.com/
  • Direct-to-consumer: no doctor's orders needed.

Dr. Lynch has now become the most vocal advocate for his patients to take HealthieOne tests.

The Price of Prevention

At $475, HealthieOne Complete costs less than:

  • A single emergency room visit ($1,500-$3,000)
  • One night in the hospital ($2,500-$5,000)
  • Cardiac catheterization ($15,000-$30,000)
  • The co-pays for lifelong heart medications

"When I think about the hundreds of thousands this test potentially saved in medical costs, not to mention my life, $475 seems almost insultingly cheap," Sarah reflects.

Real Results: Sarah's Journey Six Months Later

  • Before HealthieOne: Ticking time bomb with 317 nmol/L Lp(a)
  • After intervention:
    • Started low dose of statin and PCSK9 inhibitor therapy
    • Lp(a) reduced to 240 nmol/L (24% reduction)
    • LDL cholesterol dropped from 95 to 45 mg/dL through combination of statin therapy and PCSK9 inhibitor
    • Although diet and lifestyle changes don't lower Lp(a) levels, Sarah implemented heart-healthy dietary modifications and regular exercise to optimize her overall cardiovascular risk profile and prevent further CVD progression
    • Enrolled in clinical trial for lepodisiran
    • Comprehensive cardiovascular risk assessment completed
    • Peace of mind: priceless

The Hidden Cardiovascular Markers Standard Tests Miss

Lp(a) is just the beginning. HealthieOne Complete reveals the whole holistic view of cardiovascular health that other health test services miss:

Advanced Cardiovascular Biomarkers:

  • Aldosterone
  • Apolipoprotein A1
  • Apolipoprotein B (Apo B)
  • Arachidonic acid
  • Arginine
  • Asymmetric Dimethylarginine
  • Carnitine
  • Chloride
  • Cholesterol
  • Cholesterol HDL
  • Cholesterol LDL
  • Cholesterol Total
  • Cholesterol Total/Cholesterol HDL
  • Citrulline
  • Corticosterone
  • Cortisol
  • Cortisone
  • C-Reactive Protein
  • Docosahexaenoic Acid
  • Docosanoic Acid
  • Docosapentaenoic acid C22:5w3
  • Eicosapentaenoic acid
  • Epinephrine
  • Hematocrit
  • Histamine
  • Homocysteine free
  • Homo-Gamma-Linolenic acid
  • Hypoxanthine
  • Inosine
  • Linoleic acid
  • Lipoprotein (a)
  • Norepinephrine
  • Normetanephrine
  • Oleic acid
  • Taurine
  • Thyroxine
  • Triglycerides
  • Triiodothyronine
  • Trimethylamine N-oxide
  • And many more...

Additionally, Nutrient Deficiencies That Affect Heart Health:

  • Omega-3 fatty acid ratios
  • Magnesium status
  • B-vitamin deficiencies
  • Antioxidant levels

"I went from having no idea I was in danger to having a complete roadmap for prevention," Sarah says. "My cardiologist called me his most informed patient. I knew more about my cardiovascular health markers than he did."

"It's like getting a complete blueprint of your cardiovascular system instead of a basic sketch," explains Dr. Anne Le, CEO of HealthieOne. "We're not just looking at cholesterol numbers, we're analyzing your entire biochemical system. HealthieOne Complete is like a deep scan at the cellular and molecular level of your health."

The Cost of Not Knowing: When "Healthy" People Have Heart Attacks

Consider these sobering statistics:

  • 50% of heart attacks occur in people with "normal" cholesterol
  • 25% of heart attack victims had no traditional risk factors
  • Average age of first heart attack: 65 for men, 72 for women—but increasingly affecting people in their 40s and 50s
  • 80% of premature heart disease is preventable with early detection

The traditional medical model waits for symptoms. HealthieOne identifies problems years before they become emergencies.

What Your Doctor Probably Doesn't Know About Lp(a)

Here's an uncomfortable truth: most physicians receive minimal training on Lp(a) and other advanced cardiovascular biomarkers.

Recent survey data shows:

  • 67% of primary care doctors have never ordered an Lp(a) test
  • 43% of cardiologists don't routinely test for Lp(a)
  • Average medical school education on Lp(a): less than 2 hours
  • Most physicians are unaware of new RNA-based treatments

"The HealthieOne physician report was more comprehensive than anything my cardiologist had seen," Sarah admits.

This isn't a criticism of physicians: it's a reality of medical training that focuses on treating disease rather than preventing it.

The HealthieOne Advantage: Technology Meets Personalization

What sets HealthieOne apart from other health test services:

Advanced Technology

  • CLIA-certified laboratory meeting the highest quality and accuracy standards
  • Advanced technology trusted by Johns Hopkins, Mayo Clinic, and leading medical institutions

Doctor-Level Interpretation

HealthieOne doctors have extensive knowledge in medicine (MD) and human biochemistry and metabolism (PhD), providing:

  • Personalized recommendations based on your unique biomarker profile
  • Direct access to medical team for follow-up questions
  • Collaboration with your existing healthcare team to create a clear actionable plan:
    • Specific supplement recommendations based on your deficiencies
    • Dietary modifications tailored to your metabolic profile
    • Exercise recommendations optimized for your biomarkers
    • Treatment options including cutting-edge therapies

"It wasn't just about preventing a heart attack," Sarah explains. "I optimized my entire health profile. I have more energy, better sleep, and feel 10 years younger."

The Future is Now: Personalized Prevention Medicine

HealthieOne Complete represents the future of healthcare: personalized, predictive, and preventive.

Instead of waiting for disease to strike, you get:

  • Early warning systems for major health conditions
  • Personalized optimization strategies based on your unique biology
  • Access to cutting-edge technologies
  • Partnership with physicians

Take Action: The Test That Could Change Your Life

Ask yourself these questions:

  • Do you know your Lp(a) level?
  • Has your doctor ever tested for advanced cardiovascular markers?
  • Are you making health decisions based on complete information?
  • Could you be the 1 in 5 people with hidden genetic risk?

Don't wait for symptoms. Don't assume "normal" means healthy. Don't let your first heart attack be your wake-up call.

Order your HealthieOne Complete test today at healthieone.com

"The best time to plant a tree was 20 years ago. The second best time is now. The same is true for understanding your health." - Sarah Martinez

Ready to discover what your body is trying to tell you? Visit healthieone.com or call (667) 312-2924

HealthieOne Complete: Because your health deserves the complete picture.

References

  1. Harvard Health Publishing. (2024). Lipoprotein(a): An update on testing and treatment. Harvard Medical School. https://www.health.harvard.edu/heart-health/lipoproteina-an-update-on-testing-and-treatment
  2. O'Donoghue, M. L., López, J. A. G., Knusel, B., et al. (2024). Lepodisiran for lowering of lipoprotein(a) concentrations in patients with elevated levels: a randomised, double-blind, placebo-controlled, dose-ranging trial. New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMoa2415818
  3. Centers for Disease Control and Prevention. (2024). About Lipoprotein(a). https://www.cdc.gov/heart-disease-family-history/about/about-lipoprotein-a.html
  4. Kamstrup, P. R., Tybjaerg-Hansen, A., Steffensen, R., & Nordestgaard, B. G. (2017). Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA, 301(22), 2331-2339. https://pubmed.ncbi.nlm.nih.gov/28183512/
  5. Tsimikas, S., Gordts, P. L. S. M., Nora, C., Yeang, C., & Witztum, J. L. (2020). Statin therapy increases lipoprotein(a) levels. European Heart Journal, 41(24), 2275-2284. https://www.jacc.org/doi/10.1016/j.jacc.2016.11.042
  6. Raal, F. J., Giugliano, R. P., Sabatine, M. S., et al. (2014). Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,500 patients in 4 phase II trials. Journal of the American College of Cardiology, 63(13), 1278-1288. https://pmc.ncbi.nlm.nih.gov/articles/PMC8822604/
  7. Amgen. (2024). A Study to Evaluate the Efficacy and Safety of Olpasiran in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a). ClinicalTrials.gov. https://www.amgentrials.com/study/?id=20180109
  8. ClinicalTrials.gov. (2024). Assessing the Impact of Lipoprotein (a) Reduction With Pelacarsen on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON). https://clinicaltrials.gov/study/NCT04270760?rank=1
  9. Wikipedia. (2024). Pelacarsen. https://en.wikipedia.org/wiki/Pelacarsen