Note to Reader:

This compelling transformation represents a real-life patient success story: a 49-year-old woman who graciously allowed the HealthieOne medical team to share her anonymous health journey to help others understand the power of comprehensive health testing: https://healthieone.com/case-studies/lipoprotein-the-invisible-killer/.

What makes this case extraordinary isn't just the dramatic improvement, it's what was discovered through HealthieOne Complete's comprehensive testing that would have been completely missed by standard annual blood work. While typical annual physicals test only a handful of basic markers, HealthieOne Complete analyzes 230+ biomarkers across multiple health domains, including advanced lipid profiling, antioxidant levels, neurological health, hormonal panels, nutritional assessments, resilience and longevity markers, and cutting-edge cardiovascular risk factors.

The trend graph displays three critical data points:

• September 6, 2024: Basic annual blood test from Mercy Hospital
• June 9, 2025: First HealthieOne Complete results, revealing hidden cardiovascular risks that standard testing would never detect (doctor-interpreted results shown below)
• September 9, 2025: Results demonstrating remarkable outcomes after just three months of targeted treatment prescribed by her cardiologist:
  • Rosuvastatin 10 mg daily (Crestor)
  • Aspirin 81 mg daily
  • Repatha 140 mg subcutaneous injections every 14 days

This is the difference between knowing your basic health status and truly understanding your complete health picture. Her story illustrates why comprehensive testing saves lives, and why settling for basic annual blood work may leave the most important health insights undiscovered.

Summary Interpretation:

Thank you for choosing HealthieOne for your annual health assessment.

Your 250+ biomarker results deliver unprecedented insights into your current health status. Share this personalized, in-depth report with your healthcare provider to identify optimization opportunities and make informed decisions about your wellness journey.

Cardiovascular Health

Your LDL cholesterol level is elevated, and your non-HDL cholesterol is also slightly above optimal. Non-HDL cholesterol captures all the "bad" cholesterol-carrying particles in your blood, including LDL and VLDL, making it a comprehensive marker of atherogenic risk. These findings are particularly significant given your strong family history of heart disease, diabetes, and hypertension. This elevation, combined with your sedentary work lifestyle and high stress levels, creates a cardiovascular risk profile that needs immediate attention. While your HDL cholesterol and triglycerides remain healthy, and your inflammatory marker C-reactive protein is optimally low, the LDL and non-HDL elevations suggest your body may be producing excess cholesterol or not clearing it efficiently.

Your lipoprotein(a) level is significantly elevated, representing a genetic cardiovascular risk factor that cannot be modified through diet or lifestyle alone. This finding is particularly concerning given your strong family history of heart disease and creates an urgent need to optimize all your controllable cardiovascular risk factors. Lipoprotein(a) is largely determined by genetics and acts as an independent risk factor for heart disease and stroke. Since you cannot change this genetic predisposition, it becomes crucial to aggressively manage every other cardiovascular risk factor. 

Your trimethylamine N-oxide (TMAO) level is elevated, which is a cardiovascular risk marker that forms when gut bacteria process certain compounds found in fish, eggs, and other foods. It's important to understand that TMAO levels can be influenced by gut bacteria composition, kidney function, and dietary patterns. Since you consume fish regularly as part of your pescatarian diet, some elevation might be expected. However, optimal levels are still preferable for cardiovascular health, especially given your elevated lipoprotein(a) and family history of heart disease. 

Hormonal Health

Your 17-hydroxyprogesterone level is elevated, which may indicate adrenal stress or hormonal imbalance, particularly relevant given your history of unsuccessful IVF cycles and current high stress levels. This hormone is involved in the production of cortisol and sex hormones, and elevation can occur when your adrenal glands are working harder to manage stress or when there are disruptions in hormone metabolism. Your high stress levels and the physical and emotional toll of multiple IVF cycles could contribute to this finding. 

Your estradiol level is elevated for a post-menopausal woman, which warrants investigation given your history of unsuccessful IVF treatments and current post-menopausal status. This elevation could indicate residual effects from previous hormone treatments or other underlying factors affecting your hormone balance. Since elevated estrogen levels can have implications for cardiovascular health and other conditions, particularly in postmenopausal women, this finding needs attention. 

Recommendations: Discuss the following along with all the above findings with your healthcare providers for further guidance:

Cardiovascular Health

• Maintain optimal blood pressure and keep LDL cholesterol as low as possible through diet and potentially medication
• Increase physical activity to counteract your sedentary work environment
• Support healthy gut bacteria through probiotic-rich foods like yogurt, kefir, and fermented vegetables
• Add prebiotic foods such as garlic, asparagus, artichokes, and whole grains
• Alternate fish meals with plant-based protein sources like legumes and quinoa
• Discuss with a cardiologist within the next 2 to 3 weeks to develop a comprehensive cardiovascular risk reduction strategy and determine if additional testing (such as coronary calcium scoring or other specialized evaluations) or preventive medications are appropriate

Hormonal Health

• Focus on stress reduction techniques such as regular meditation, deep breathing exercises, gentle yoga, or other relaxation practices
• Ensure adequate sleep of 7 to 9 hours nightly
• Discuss hormonal results with your gynecologist or endocrinologist to determine if further evaluation is needed

• Retest lipid, hormone panels, TMAO in 3 to 4 months

The HealthieOne Follow-up test will include all the recommended follow-up blood tests mentioned above, offering personalized retesting of your abnormal markers from your HealthieOne Complete test and efficiently tracking your progress.

Your biological age is 44, which is younger than your chronological age of 49.

After reviewing your test results, we encourage you to take advantage of our ongoing health support. Our HealthieOne doctors are available through our secure live 1:1 consultation to answer  any questions you may have, and collaborate with you and your healthcare providers to optimize your health based on your unique profile.

We've designed our comprehensive test specifically to connect the dots linking your health background, biochemistry, and lifestyle factors to uncover the deeper causes of health issues. Our reports are intentionally crafted to be both thorough and accessible, making it easier for you and your healthcare team to collaborate effectively. This holistic approach transforms isolated data points into actionable insights that support your long-term health journey. 

Warmly,
The HealthieOne Team